Ganglioglioma
Ganglioglioma are primary brain tumours that emerge from glia- and neuroplastic ganglion cells. According to WHO classification it is mostly classified as WHO grade I.
Histology of Ganglioglioma
- mainly slowly growing tumour WHO grade I
- also WHO grad II and III can occur
- emerge from neoplastic ganglion cells (neural cells) and glia cells (provide support and protection of neurons)
Epidemiology of Ganglioglioma
- especially in children and young adults
- represent less than 2% of all primary brain tumours
Symptoms of Ganglioglioma
- epileptic seizures
- signs of intracranial pressure (headache, nausea, emesis)
- symptoms related to localisation
Diagnosing Ganglioglioma
- irregular and slight enhancement of contrast agent in MRI
- clearly defined lesion
- usually feature cysts
- in 35-50% of the cases calcifications
- can basically occur in the entire CNS
- main localisation in frontal lobe
Therapy of Ganglioglioma
- surgery (if possible complete resection of the tumour)
- in anaplastic tumours (WHO grade III) postoperative treatment with radiotherapy and/or chemotherapy
Course of Ganglioglioma
- astrocytic parts rarely transform to WHO grade III or glioblastoma
Prognosis of Ganglioglioma
- favorable prognosis
- after complete surgical removal normal life expectancy can frequently be reached
